The role of each individual nutrient at work in our bodies never ceases to amaze me.
Frank M. Painter, D.C., provided this job description of the mineral magnesium, noting that eight out of ten Americans get less than the recommended levels of magnesium in their diets:
It may be a humble element, but it’s a lot more than just a flash in the pan!
Magnesium is the fourth most abundant mineral in the body. It is involved in more than 300 biochemical processes, including maintaining normal muscle and nerve function, supporting the immune system, regulating blood sugar levels, promoting normal blood pressure, and managing energy metabolism and
protein and nucleic acid synthesis.1 Isn’t that a mouthful!
Treatment with diuretics (water pills), some antibiotics, and some medicine used to treat cancer, such as Cisplatin, can increase the loss of magnesium in urine. Other causes of magnesium loss and deficiency include poorly controlled diabetes and alcohol use. Signs of magnesium deficiency include confusion, disorientation, loss of appetite, depression, muscle contractions and cramps, tingling, numbness, abnormal heart rhythms, coronary spasm, and seizures.
Let’s look at the spectrum of illnesses associated with magnesium deficiencies:
Pregnancy-related Illnesses:
Some pregnant women experience either gestational diabetes (glucose intolerance of pregnancy) or pre-eclampsia/eclampsia (pregnancy-induced hypertension and toxemia). Both are very dangerous to the mother and are also associated with spontaneous abortions. Early studies of women experiencing toxemia in pregnancy at the Tuskegee Institute correlated lower intake of vitamins and minerals with the severity of their illness.2 A 1992 clinical trial with pregnant women with family histories of hypertension found that magnesium supplementation dramatically reduced the incidence of pre-eclampsia in the supplementation group.3
A 1987 double-blind, placebo-controlled study of women experiencing premenstrual syndrome (PMS) revealed laboratory evidence of significant deficiencies in vitamin B6 and magnesium. Using a multivitamin/multimineral supplement corrected some of these deficiencies and, at the appropriate dosage, improved the symptoms of premenstrual tension.4
Heart Disease:
Sudden death associated with ischaemic heart disease occurs more frequently in areas in which soil and drinking water lack magnesium. It is also associated with heart arrhythmias, and the use of magnesium for treating one or the other arrhythmia has been recommended.5
Diabetes:
A retrospective study of 85,060 women and 42,872 men found an inverse association between magnesium intake and diabetes risk, and recommended increased
consumption of magnesium for prevention.6
Asthma:
Magnesium is extremely effective in the relaxation of bronchial smooth muscle tissue, resulting in a reduction of bronchospasm and increased airways diameter. Magnesium has also been demonstrated to reduce the histamine response. Patients who suffer from allergy related asthma often show excessive eosinophilic and basophilic histamine release which ultimately results in bronchoconstriction.
Ironically, studies have shown asthma medications such as theophylline and the beta agonists (such as albuterol and metaproterenol) can cause magnesium wasting. This may result in exacerbation of the overall condition.7 Magnesium supplementation is an effective conservative approach to the management of the bronchospasm component of asthma.
Osteoporosis:
Magnesium regulates active calcium transport in the blood. As a result, there has been a growing interest in the role of magnesium (Mg) in bone metabolism. A group of menopausal women were given magnesium hydroxide to assess the effects of magnesium on bone density. At the end of the 2-year study, magnesium therapy appears to have prevented fractures and resulted in a significant increase in bone density.8
References:
1 NIH’s Magnesium page at
http://ods.od.nih.gov/factsheets/magnesium.asp
2 Intakes of Vitamins and Minerals by Pregnant Women with Selected Clinical Symptoms
J Am Diet Assoc 1981 (may); 78 (5): 477-482
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3 Effects of a Combination of Evening Primrose Oil (Gamma linolenic acid) and Fish Oil (Eicosapentaenoic + Docahexaenoic acid) versus Magnesium, and versus Placebo in Preventing Pre-eclampsia
Women Health 1992; 19 (2-3): 117-131
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4 Clinical and Biochemical Effects of Nutritional Supplementation on the Premenstrual Syndrome
J Reprod Med1987 (Jun); 32 (6): 435-441
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5 Magnesium in Supraventricular and Ventricular Arrhythmias
Zeitschrift fur Kardiologie 1996; 85 Suppl 6: 135-145
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6 Magnesium Intake and Risk of Type 2 Diabetes in Men and Women Diabetes Care 2004 (Jan); 27 (1): 134-140
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7 Research Perspectives in Asthma: A Rationale for the Therapeutic Application of Magnesium, Pyridoxine, Coleus forskholii and Ginkgo biloba in the Treatment of Adult and Pediatric Asthma
The Internist 1998 (Sept); 5 (3): 14″16
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8 Magnesium Supplementation and Osteoporosis
Nutrition Reviews 1995; 53 (3): 71-74
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